The cast of a television show is often compared to a family. How devastating to the show was it to cast members. How did the show fare after the loss?
| Actor | Show | Character | Details |
| Bea Benederet | Petticoat Junction | Kate Bradley | Died October 13, 1968 after 169 episodes of 222 |
| Dan Blocker | Bonanza | Hoss Cartright | Died May 13, 1972 after 415 episodes of 430 |
| Diana Hyland | Eight is Enough | Joan Bradford | Died March 27, 1977 after 4 episodes of 112 |
| Jerry Orbach | Law & Order: Trial by Jury | Lennie Briscoe | Died December 28, 2004 after 2 episodes of 13 |
| Jim Davis | Dallas | Jock Ewing | Died April 26, 1981 after 77 episodes of 357 |
| John Ritter | 8 Simple Rules | Paul Hennessy | Died September 11, 2003 after 30 episodes of 76 |
| Jon-Erik Hexum | Cover UP | Mac Harper | Died October 18, 1984 after 7 episodes of 11 |
| Michael Conrad | Hill St. Blues | Sgt. Phil Esterhaus | Died November 2, 1983 after 71 episodes of 116. |
| Nicholas Colasanto | Cheers | Coach | Died February 12, 1985 after 70 episodes of 270 |
| Phil Hartman | NewsRadio | Bill McNeal | Died May 28, 1998 after 75 episodes of 97 |
| Richard Biggs | Strong Medicine | Dr. Milo Morton | Died May 22, 2004 after 15 episodes of 131. |
| Redd Foxx | The Royal Family | Alphonso Royal | Died October 11 1991 after 7 episodes of 15 |
| Stanley Kamel | Monk | Dr. Charles Kroger | Died April 8, 2008 after 43 episodes of 125 |
- Alice Pearce appeared as Gladys Kravitz in Bewitched 27 times prior to her death on March 3, 1966. The character Mrs. Kravitz appeared 51 times in Bewitched which aired 254 episodes.
